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A Midwestern Doctor's avatar

If you have had a DMSO report you'd like to share, please do so here:

https://www.midwesterndoctor.com/p/the-remarkable-history-and-safety/comments

When they are posted in other places, despite my best efforts, they frequently get missed and don't make it up there.

Additionally, the most current information on using DMSO can be found in this article:

https://www.midwesterndoctor.com/p/dmso-heals-the-eyes-and-transforms

There are a lot of other DMSO articles in the cue, but I made a decision I needed to do a much more comprehensive review of the literature first (manually going through ~50,000 studies and sorting the 5,000 comments I've received) as certain studies needed to write the future articles cannot be found in any other manner. I'm hoping to have the next one done at the end of December or start of January.

Thank you so much for your support and understanding.

INGRID C DURDEN's avatar

MD you are a miracle in yourself. Thank you for your articles, that certainly have helped numerous people!

Anna Lafferty's avatar

thanks for your diligence and generosity, AMD!

Michelle Dostie's avatar

Midwestern Doctor: Interestingly, I read Dr. Bresden’s first book 5 years ago, and clicked on the link for the book by Dr Doige. I found it on my shelf, but need to reread it. I remember it being fascinating. My question is whether reading is an activity that creates the necessary environment for a continued avoidance of dementia, since the synapses are constantly working? It would be good to know as it is much more compelling than any other activity, except healthy diet on a daily basis, and intermittent fasting.

Also, is DMSO sitting in the health food store waiting for me to buy it? Should I get a doctor’s approval first?

Lori's avatar

Jacob Labs is a DMSO source that AMD has recommended on her previous SS articles on DMSO. I purchase from there and they offer different strengths and in amber glass bottles. Hope this helps.

Michelle Dostie's avatar

AMD is a male, I think. From his picture and the name in his book I bought. I will check the book again!

Lori's avatar

Oh, interesting. What is the name of the book as I am not familiar?

Michelle Dostie's avatar

It is about heart health. “Heart An Owner’s Guide” Dr. Paddy Barrett

Lori's avatar

Don't believe this is AMD though.

Lori's avatar

Thank you Michelle!

Sue's avatar

Thank you!!!

Trish Vanaria's avatar

I would love to know how much oral DMSO to take prophylactically for cognitive decline (and how often). I am 65 110 lbs and would like to maintain (and possibly improve) my brain function as long as possible. I'm sure the answer is embedded in one of your articles but I would sure appreciate the answer as I have not located that information. Thank you for all you do!

TAS's avatar
Dec 14Edited

Ive asked the same question many times. I dont think it’s legal for MD to respond perhaps? I sure wish there was a simple chart like so many other therapies stating: Age/Weight take this much for “dementia”…..ect

JC's avatar

it's because we are each an experiment of N=1. You & I might weight the same, but some other difference means we react differently. General rules, 30% for sensitive areas, 20% for mouth, ear, nose & throat, 70% for strong pain. Ingestion is 1 tsp in a glass of juice (that's an automatic dilution and your body dilutes further)

But how it reacts for you, how well it works for you? That's what the N=1 experiment is all about. And really, why no doctor, except those versed in DMSO and how it works, could help you with.

Andrea Mary King's avatar

I do to! I am wanting to take DMSO for early intervention. My mother and two of her sisters passed away from dementia. I’m pretty good at the moment, but I’d like to have a preventative amount.

dumerican's avatar

A more recent article from amd was published just the other day icymi, re Alzheimer's treatment involving UV light from a small amount of patient's blood in a transfusion, and reinjecting the blood back. Apparently it was highly successful but not profitable enough for AMA, who then manipulated successive tests to fail. Currently Germany and Russia are successfully using a similar treatment for many disorders including Alzheimers...

Kelly Loomis's avatar

Read the “link to the longer article” in the conclusion. It gives amounts and where to find pure DMSO.

Trish Vanaria's avatar

I do believe I read that at some point, but I’ll go back - did I mention I have ADD also ☺️?

TAS's avatar

I must have missed that in the long article. Ill go back and look.

TAS's avatar

Weirdly my comment back to you about using dmso without a filter has disappeared….weird.

West Coast Biochemist's avatar

I’ve closely read most of the DMSO articles. Here’s what I have gleaned about dosing:

1, it’s nearly impossible to overdose (it is extremely safe even at doses that most people would not take, eg, MUCH more than a couple tablespoons)

2, MWD has repeatedly advised to start small and work up from there, paying attention to how you feel and if any reactions occur (this is most applicable to topical applications but I’d assume the same logic applies to oral dosing, to a certain extent)

3, some people experience strong and unpleasant odor, and the higher the dose, the worse the odor. So your tolerable dose might come down to odor tolerance

4, I saw a comment in another article that someone’s parent started taking 1tsp each day with 8oz juice and it substantially improved cognition - the person was non-verbal (or close to it) and was able to begin talking again and recognizing people

Hope this helps! :)

Trish Vanaria's avatar

Thank you for this! I have a brown glass bottle (16 oz) of DMSO I purchased from Amazon and had been using topically. Given I want to ingest, I found another brand with a small dropper bottle I thought I'd purchase as well (I can refill with my original bottle when I use it up) figuring it would have some dosage lines on the dropper. As it turns out, it has .25 - 1.0 mg's so I have started with .25 and will work my way up. The 16 oz bottle has no garlic taste/smell (which it sights is POSSIBLE to not have that at all and have the same quality product, hurray! My underarms were actually starting to smell like garlic - not good!). So far no difference that I can tell but not sure I was expecting anything obvious at this point. Thank you again for all that information!

kmvause's avatar

We purchase our DMSO from the DMSO Store on amazon. It was one of the brands given in another article. We have used this one both externally and internally for more than a year. We find a roll on version very useful for external use.

Lena's avatar

Sometimes all we have to do is Google search what we need. WMD has provided so much info for us so its up to us to find it. I use DuckDuckGo as a search engine and I simply searched a few words like DMSO benefits and look what I found with a 5 word search. It truly is not as complicated as we think. A lot of answers are in this handbook. Save it to your computer for future reference.

https://www.eden-shop.eu/wp-content/uploads/2020/06/Scott-Archie-DMSO-Handbook.pdf

Trish Vanaria's avatar

Sorry Lena, not one sentence on dosage. Just confirming what we already know - that it helps and the earlier you start the better.

Lena's avatar

I frequently read several sources. The common dosing varies for everyone. I hear things like 1 tablespoon 2x per day or 1 tsp 3 x per day with water. Since it isn't an approved treatment by any officials, we have to use our common sense. No one can tell you how much to take. They would risk getting their license yanked if they did. So you have to take that risk yourself. We are in a new era of self medicating, since doctors don't have a clue. There is always a risk with self medicating. How much are you willing to gamble for your health? No one is responsible for you. I get tired of people asking for dosing because they resist taking responsibility for themselves.

Carol Eckelkamp's avatar

I’m asking for information on how to take DMSO orally and how to find a doctor who will help you with it. Thanks very much for this information and for all you do!

DUANE HAYES's avatar

You'll search high and low to find such a doctor. My guess, maybe 6-8 in the United States.

Lena's avatar

Check out my answer and link above.

Brad Thompson's avatar

Excellent article on DMSO healing benefits. What I don’t see from reading many of these articles is how DMSO is to be administered. I did do a reasesrch for DMSO for eye health (1-2 drops 1-2 times a day) but almost never am I able to find DMSO administration for other diseases / chronic ailments such as Alzheimers. Thank you.

Lena's avatar

You can find all of it on this substack. Just go to her archived list. Sometimes we just have to look.

Mouzer's avatar

MWD has written a series on DMSO, articles for particular issues as well as multiple instructions on various ways to use it for different issues, dosages, strengths and so on. They are all posted on the site.

Steven Wood's avatar

No dosages given, no applications given on oral or IV given in any articles, it’s frustrating to read all of these articles with the most important information left out.

Kelly Loomis's avatar

Read the link to the longer article in the conclusion. It gives dosages in the conclusion.

INGRID C DURDEN's avatar

China recently developed a surgery (detailed here) to increase the lymphatic drainage from the brain. Due to its and low cost... There is a word missing here.

Very interesting article. Too late for my mom, she passed away in June, and dad probably would not have tried anything their own doctor did not subscribe to, which was a pity. I think one should try everything to help a suffering person! (and not euthanize them like Canada does nowadays)

A Midwestern Doctor's avatar

Fixed, apologies.

Stuart Hutt's avatar

The brain drains through the glymphatic system and replaces the cholesterol every 10 months. The brain makes its own cholesterol which a statin can reduce.

Deborah's avatar

My great-grandmother 1962, my grandmother 1989, a great aunt 1990's, my mother Sept 2018, my aunt Feb 2025.

Don's avatar
Dec 14Edited

The missing word (guessing) appears to be efficacy (?).

"Due to its efficacy and low cost..."

Thomas A Braun RPh's avatar

Excellent article! It’s time our medical schools stop embracing the concept that disease states always require chemical intervention! Time to put medical treatment back in the hands of physicians who are properly educated.

Understanding the physiology of the body has to be basic ! A brilliant physician that I met, who has now passed treated brain trauma with vitamin D and 3 Omega and other nutrients. He did a comparative study between his results and his cohort.. on a lifetime basis he saved 279 more patients who had to recover from traumatic brain injury, many of which were gunshot wounds. There is also a book called excitotoxins that discuss that artificial sweeteners like aspartame contribute to inflammation of the brain and the development of Alzheimer’s.. my friend‘s wife insisted on putting five equal packets into her cup of tea every day. She acquired Alzheimer’s.. it’s a slow process, but in my view is a chemical addiction and should’ve never been approved as a sweetener. There is a documentary published a good 25 years ago, called sweet misery and explains how it all came about which was a political act.! All you have to do is stand outside the lobby of a Costco and watch whose baskets are filled with a case of diet pop! they have the chemical addiction and can’t understand their weight gain is from the chemical addiction.

I will publish your article and include a reference to Dr. Leslie Matthews study .

He also was an international champion of the true value of vitamin D, and is responsible for convincing the FDA to include vitamin D content on food labels.

Barbara Charis's avatar

I did write about this previously that a friend died of Alzheimers from using an aluminum coffeemaker. Aluminum causes brain damage. It is in many products that people are using. . I warned her, about the aluminum in 1961. My father had sent me an article from St Catharine's Press in Ontario Canada... It is interesting that there were people who knew the danger of ingesting aluminum...68 years ago!

Mouzer's avatar

Silica rich water helps remove Al. There are several on the market. I take BioSil, which has the same version of silica these waters have.

Reader East of Albuquerque's avatar

Fiji water has a high level of silica I understand. Also Volvic.

JC's avatar

Diatomaceous earth is rich in silica, also

Mouzer's avatar

Diatomaceous earth (DE) contains solid, amorphous silica (SiO₂·nH₂O) that exists as microscopic, rigid frustules (the shells of fossilised diatoms).

Orthosilicic acid (H₄SiO₄) is the molecular, water‑soluble form of silica that is present in “high‑silica” natural waters. BioSil contains a stabilized form of orthosilicic acid.

Because of these structural differences, DE silica is essentially insoluble and behaves like a fine mineral powder, whereas orthosilicic acid remains dissolved, is chemically reactive, and can be taken up by organisms as a source of bioavailable silicon.

Rabid Homebody's avatar

Mouzer, on Vitacost's website, I noticed that they offer different BioSil products. Can you tell me the specific BioSil product you use? Thank you.

Mouzer's avatar

liquid collagen generator, nothing added

Aly Jaenicke's avatar

A family friend’s wife 80 years old and is in perfect health had two covid vaccines and developed severe Alzheimer’s disease within 6 months of the vaccine.

She’s in a special care home now.

She’s a vegetable basically.

Her primary care doctor dismissed the Alzheimer’s vaccine connection of course.

Mouzer's avatar

My friend had every booster. Now she isn't mentally as functional, though encouraging her (actually deliberately terrifying her) to get help may have kept her from going down quite as fast.

DUANE HAYES's avatar

My brilliant aero space engineer cousin went full blown dementia within 2-3 moths of her mRNA injections and boosters, died in a car wreck she caused. She was going to a doctor appt 10 minutes away, got lost and drove hundreds of miles.

Donna's avatar

Based on my own experience, I believe whatever neurotoxin is in the shot, was also in the Covid bioweapon "flu". Although not as extreme, I have been experiencing cognitive issues since sickened with the bioweapon in July 2023.

aprayerformonkey's avatar

Same here. It is astounding to me that so many people think our government is evil enough to make a kill shot, but not evil enough to engineer a kill virus [ or whatever it actually was ] I divide my life into before covid and after covid. Try Lumbrokinase.. It helped bring my antibodies down.

Donna's avatar

Thanks for the tip. It is my belief the government knew not everyone would comply with the shot, so they released the bioweapon via another method in order to effect as much of the population with it as possible. It's probably the reason for long Covid. Who ever had long term after effects from any normal flu seasons?

aprayerformonkey's avatar

I think also Dr Kory has a protocol. The changed their name, so just typing it into the search bar would bring it up. Post viral infection has been around for a long time, but so have vaccines, so you never know. Before the 1800's, they might of called it something else. Beth [ Little Women ] died from complications of scarlet fever [ Strep ] Acute infections can cause lifetime disorders like autoimmune issues which then become a problem of their own. And remember- nature allowed the weak to die, so the paradigm shift of keeping people alive and passing their sick genetic codes onto multiple generations is an experiment in process. If you want to know how it's coming along, a slow stroll down the aisles of Walmart after 10:pm will educate you.

Aly Jaenicke's avatar

If I were you I would be looking into detoxing the spike.

Perhaps you’re experiencing excessive spike.

There is a test that Labcorp offers to check your spike levels.

I heard that it’s about $70.00 dollars.

Travis Ogle's avatar

Big Pharma treats Alzheimer’s disease the same way they treat cancer. I’m not speaking about prescription drugs or standard treatments, but the outstretched hand for donations for what they claim will be used for research to find a cure. That nonsense has provided an uninterrupted stream of funds designed to continue without pause.

GeeWiz, we forgot to look at the abundance of examples where improvements have occurred without our patented products. When the purpose of your funded “research” is to prove the efficacy of your existing drugs, while ignoring other treatments that do work, your creditably has vanished down the toilet where it belongs.

Garry Blankenship's avatar

There you go again; being skeptical of repeat convicted felons creating the best of injectables for us all.

AMV's avatar

This article is amazing and informative. More than we’ll ever hear from the propaganda machine! Thank you! 😊

Robert Welch's avatar

I thought of Crocodile Dundee ( " Now this is a knife " ) when reading about sleeping pills :

" ....and have a variety of issues.......( e.g., they make users 2-5 times as likely to die.

Death, " Now this is an issue !! ) LOL.

JC's avatar

My sis-in-law had a car accident, Christmas week. "Sleep driving." Yep. One of those.

She's fine, but still taking the drug....with caveats, but still taking it.

Robert Welch's avatar

Wow, hard to believe such could happen.

( A caveat being - chained to the bed ? )

I have a friend who had suffered from not being able to sleep who started taking the green stuff that rhymes with " you wanna marry me ", sort of, at night and now gets really good sleep. Her personality/energy has vastly improved, as a result.

Stuart Hutt's avatar

I believe the amyloid plaque theory has been debunked. Dr Christopher Exley (Substack) has shown toxic levels of aluminum in brain biopsies of Alzheimer and autism patients. 42 out of 45 vaccines have aluminum adjuvants. A macrophage can uptake aluminum and cross into the brain. Dr Robert Yokel (University of Kentucky) released a study May 2025 showing the average American adult consumes over 4lb of aluminum annually in food/drink. Dr Coimbra (Coimbra Protocol) uses high dose D3 to reverse Alzheimer, autism, MS, psoriasis with a high success rate. D3 is a prohormone that all tissue cells are looking for, including the brain. The brain is 50% cholesterol by dry weight which is replaced every 10 months. D (1,25dihydroxy) is used to make macrophages and immune signaling. Dr Exley has found that natural spring water high in silica chelates aluminum from the body.

I can also see the benefit of DMSO in batting many neurological diseases.

Nancy Barritt's avatar

I appreciate your articles so very much! Thank you for the truth. But I do think that you are so busy, that you might not even know that whoever is proofing your finished copy, is missing so many mistakes in grammar. I stopped counting after seeing 12 grammatical errors in this article alone.

Go west's avatar

I engage and appreciate experience, content and education; my focus isn’t on counting grammatical errors and editing.

Deb.Butler's avatar

But those grammatical errors reflect on the author, unfortunately

Donna's avatar

Yes, the devil is always in the details.

Deb.Butler's avatar

I have offered to proofread for AMD, but AMD never responded

aprayerformonkey's avatar

I am a founding member of the grammar police and it drives me crazy. I had to get over it or I was going to lose my mind.

caerol's avatar

I guess you never read Agatha Christie's books. Don't do it if that affects you so much.

Don Bishop's avatar

"Large population studies show that higher homocysteine levels predict faster cognitive decline and a greater risk of dementia [6][10]. These relationships are consistent, and they follow a clear pattern: the higher the level, the faster the decline.

"Researchers also understand why this happens. Homocysteine places strain on the brain in multiple ways. It injures the lining of small blood vessels, increases oxidative stress, disrupts methylation and accelerates the atrophy characteristic of Alzheimer’s disease [1][2].

"But the strongest evidence comes from intervention. In the Oxford trials, people with raised homocysteine who were given vitamin B6, B12 and folate experienced a remarkable slowing of brain shrinkage. In those with sufficient omega 3, the reduction in atrophy reached up to 73 per cent [3]. Cognitive decline slowed or even stopped for many participants [4]. When changing a factor changes the outcome, that factor can be considered causal."

https://foodforthebrain.org/the-midlife-biomarker-proven-to-drive-alzheimers-and-how-to-bring-it-down/?utm_source=Food+for+the+Brain+Foundation&utm_campaign=8c6e5ced46-sunday_blast_7_12_25_COPY_03&utm_medium=email&utm_term=0_47a885e6cd-8c6e5ced46-290045410&mc_cid=8c6e5ced46&mc_eid=76fd273bd9

Deb.Butler's avatar

#1 The majority of people with high homocysteine also have MTHFR genetic SNPs. #2 I am one of those people. My homocysteine is consistently high. I am 73, and I have experienced no mental decline.

If your homocysteine is high, the pressure in your eyes is most likely also high, what is called glaucoma.

Deb.Butler's avatar

If you can lower your homocysteine level, the pressure in your eyes will go down also